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149 RESULTS WITHIN 50km FROM Philadelphia, United States
45-16 Ramsey Road, Shirley, NY 11967, USA, Shirley, NY
Tel: 6316197922
Lysine-specific histone demethylase 1A (KDM1A) also known as lysine (K)-specific demethylase 1A (LSD1) is a protein in humans that is encoded by the KDM1A gene.LSD1 is a flavin-dependent monoamine oxidase which can demethylate mono- and di-methylated lysines specifically histone 3 lysines 4 and 9 (H3K4 and H3K9).This enzyme can have roles critical in embryogenesis and tissue-specific differentiation as well as oocyte growth. KDM1A was the first histone demethylase to be discovered though more than 30 have been described.... read more
Tel: 6316197922
Lysine-specific histone demethylase 1A (KDM1A) also known as lysine (K)-specific demethylase 1A (LSD1) is a protein in humans that is encoded by the KDM1A gene.LSD1 is a flavin-dependent monoamine oxidase which can demethylate mono- and di-methylated lysines specifically histone 3 lysines 4 and 9 (H3K4 and H3K9).This enzyme can have roles critical in embryogenesis and tissue-specific differentiation as well as oocyte growth. KDM1A was the first histone demethylase to be discovered though more than 30 have been described.... read more
45-16 Ramsey Road, Shirley, NY 11967, USA, Shirley, NY
Tel: 6316197922
Lymphocyte function-associated antigen 1(LFA-1) is part of the family of leukocyte integrins that are recognised by their common β-chains (β2 CD18). It is found on all T-cells and also on B-cells macrophages and neutrophils and is involved in recruitment to the site of infection. It binds to ICAM-1 on antigen-presenting cells and functions as an adhesion molecule. It is the first to bind T-cells to antigen-presenting cells and initially binds weakly.... read more
Tel: 6316197922
Lymphocyte function-associated antigen 1(LFA-1) is part of the family of leukocyte integrins that are recognised by their common β-chains (β2 CD18). It is found on all T-cells and also on B-cells macrophages and neutrophils and is involved in recruitment to the site of infection. It binds to ICAM-1 on antigen-presenting cells and functions as an adhesion molecule. It is the first to bind T-cells to antigen-presenting cells and initially binds weakly.... read more
45-16 Ramsey Road, Shirley, NY 11967, USA, Shirley, NY
Tel: 6316197922
Melanin-concentrating hormone receptor 1 also known as MCH1 is one of the melanin-concentrating hormone receptors found in all mammals. The protein encoded by this gene a member of the G protein-coupled receptor family 1 is an integral plasma membrane protein which binds melanin-concentrating hormone. The encoded protein can inhibit cAMP accumulation and stimulate intracellular calcium flux and is probably involved in the neuronal regulation of food consumption. Although structurally similar to somatostatin receptors this protein does not seem to bind somatostatin.... read more
Tel: 6316197922
Melanin-concentrating hormone receptor 1 also known as MCH1 is one of the melanin-concentrating hormone receptors found in all mammals. The protein encoded by this gene a member of the G protein-coupled receptor family 1 is an integral plasma membrane protein which binds melanin-concentrating hormone. The encoded protein can inhibit cAMP accumulation and stimulate intracellular calcium flux and is probably involved in the neuronal regulation of food consumption. Although structurally similar to somatostatin receptors this protein does not seem to bind somatostatin.... read more
45-16 Ramsey Road, Shirley, NY 11967, USA, Shirley, NY
Tel: 6316197922
Potassium voltage-gated channel (abbreviated as KCNA3) belongs to shaker-related subfamily of member 3. KCNA3 encodes the voltage-gated Kv1.3 channel which is expressed in T and B lymphocytes. All human T cells express roughly 300 Kv1.3 channels per cell. From a functional and structural point of view KCNA3 is the most complex voltage-gated ion channel. As a central channel with a divergent filter property consisting of a homotetramer and four transmembrane protein subunits KCNA3 channel can conduct ions which can make the potassium ions pass smoothly. There will be one or two P-loop regions on each transmembrane protein subunit. P-loop is... read more
Tel: 6316197922
Potassium voltage-gated channel (abbreviated as KCNA3) belongs to shaker-related subfamily of member 3. KCNA3 encodes the voltage-gated Kv1.3 channel which is expressed in T and B lymphocytes. All human T cells express roughly 300 Kv1.3 channels per cell. From a functional and structural point of view KCNA3 is the most complex voltage-gated ion channel. As a central channel with a divergent filter property consisting of a homotetramer and four transmembrane protein subunits KCNA3 channel can conduct ions which can make the potassium ions pass smoothly. There will be one or two P-loop regions on each transmembrane protein subunit. P-loop is... read more
45-16 Ramsey Road, Shirley, NY 11967, USA, Shirley, NY
Plecanatide CAT#10-101-170 CAS No.467426-54-6 DescriptionPlecanatide is similar to uroguanylin and structurally related to human uroguanylin. Plecanatide acts as a guanylate cyclase-C (GC-C) agonist. Both plecanatide and its active metabolite bind to GC-C and act locally on the luminal surface of the intestinal epithelium to stimulate secretion of intestinal fluid. Synonyms/Alias(3-Glutamic acid(D>E))human uroguanylin (UGN) Molecular FormulaC65H104N18O26S4 M.W/Mr.1681.88626 SequenceH-Asn-Asp-Glu-Cys-Glu-Leu-Cys-Val-Asn-Val-Ala-Cys-Thr-Gly-Cys-Leu-OH Labeling TargetGuanylate cyclase-C (GC-C) ApplicationPlecanatide is used for the treatment of chronic idiopathic constipation (CIC). ActivityAgonist... read more
Plecanatide CAT#10-101-170 CAS No.467426-54-6 DescriptionPlecanatide is similar to uroguanylin and structurally related to human uroguanylin. Plecanatide acts as a guanylate cyclase-C (GC-C) agonist. Both plecanatide and its active metabolite bind to GC-C and act locally on the luminal surface of the intestinal epithelium to stimulate secretion of intestinal fluid. Synonyms/Alias(3-Glutamic acid(D>E))human uroguanylin (UGN) Molecular FormulaC65H104N18O26S4 M.W/Mr.1681.88626 SequenceH-Asn-Asp-Glu-Cys-Glu-Leu-Cys-Val-Asn-Val-Ala-Cys-Thr-Gly-Cys-Leu-OH Labeling TargetGuanylate cyclase-C (GC-C) ApplicationPlecanatide is used for the treatment of chronic idiopathic constipation (CIC). ActivityAgonist... read more
45-16 Ramsey Road, Shirley, NY 11967, USA, Shirley, NY
Tel: 6316197922
The Inhibition of DHODH During last decades researchers had discovered a large number of DHODH inhibitors such as leflunomide brequinar teriflunomide (A77 1726) benzimidazole and so on. Leflunomide is an approved DHODH inhibitor that has been widely used for the treatment of arthritis. As classic DHODH inhibitors leflunomide and its active metabolite A77 1726 have been demonstrated to suppress cell proliferation or to induce cell death in various tumors. Importantly DHODH inhibition by leflunomide induced a significant decrease in melanoma growth both in vitro and in vivo studies. Similarly brequinar sodium is another DHODH inhibitor that showed anti-tumour effect in... read more
Tel: 6316197922
The Inhibition of DHODH During last decades researchers had discovered a large number of DHODH inhibitors such as leflunomide brequinar teriflunomide (A77 1726) benzimidazole and so on. Leflunomide is an approved DHODH inhibitor that has been widely used for the treatment of arthritis. As classic DHODH inhibitors leflunomide and its active metabolite A77 1726 have been demonstrated to suppress cell proliferation or to induce cell death in various tumors. Importantly DHODH inhibition by leflunomide induced a significant decrease in melanoma growth both in vitro and in vivo studies. Similarly brequinar sodium is another DHODH inhibitor that showed anti-tumour effect in... read more
45-16 Ramsey Road, Shirley, NY 11967, USA, Shirley, NY
Inhibition of CCKA Application of CCK-AR antagonists can offset the reduction in food intake and satiety caused by a high-fat diet. Intravenous injection of the CCKA receptor antagonist loxiglumide can significantly reduce dietary satiety and nausea and reduce the pressure during bloating. The use of the CCK-AR antagonist loxiglumide increases insulin secretion without changing the original sugar intake and eliminates all pathways for postprandial secretion of the pancreatic polypeptide. Dexloxiglumide is a right-handed body of loxiglumide. It is a potent and selective CCK1 receptor antagonist for the treatment of constipation-type irritable bowel syndrome. It is the most advanced CCK1 in... read more
Inhibition of CCKA Application of CCK-AR antagonists can offset the reduction in food intake and satiety caused by a high-fat diet. Intravenous injection of the CCKA receptor antagonist loxiglumide can significantly reduce dietary satiety and nausea and reduce the pressure during bloating. The use of the CCK-AR antagonist loxiglumide increases insulin secretion without changing the original sugar intake and eliminates all pathways for postprandial secretion of the pancreatic polypeptide. Dexloxiglumide is a right-handed body of loxiglumide. It is a potent and selective CCK1 receptor antagonist for the treatment of constipation-type irritable bowel syndrome. It is the most advanced CCK1 in... read more
45-16 Ramsey Road, Shirley, NY 11967, USA, Shirley, NY
Chalcones Catalog Product Name CAS Number B0005-158407 2' 4'-Dihydroxy-2 3' 6'-trimethoxychalcone 100079-39-8 1044743-35-2 3'-Methylflavokawin 1044743-35-2 3'-Methyl-4-O-methylhelichrysetin 109471-13-8 Asebotin 11075-15-3 112408-67-0 3-Deoxysappanchalcone 112408-67-0 118266-99-2 Isodorsmanin A 118266-99-2 1190225-47-8 Sarcandrone A 1190225-47-8 1190225-48-9 Sarcandrone B 1190225-48-9 Loureirin A 119425-89-7 119425-90-0 Loureirin B 119425-90-0 B0005-188552 Ethyllucidone 1195233-59-0 B0005-161896 Sulfuretin 120-05-8 120926-46-7 Isoliquiritin apioside 120926-46-7 123316-64-3 2'-O-Methylhelichrysetin 123316-64-3 129724-43-2 2' 4'-Dihydroxy-3' 6'-dimethoxychalcone 129724-43-2... read more
Chalcones Catalog Product Name CAS Number B0005-158407 2' 4'-Dihydroxy-2 3' 6'-trimethoxychalcone 100079-39-8 1044743-35-2 3'-Methylflavokawin 1044743-35-2 3'-Methyl-4-O-methylhelichrysetin 109471-13-8 Asebotin 11075-15-3 112408-67-0 3-Deoxysappanchalcone 112408-67-0 118266-99-2 Isodorsmanin A 118266-99-2 1190225-47-8 Sarcandrone A 1190225-47-8 1190225-48-9 Sarcandrone B 1190225-48-9 Loureirin A 119425-89-7 119425-90-0 Loureirin B 119425-90-0 B0005-188552 Ethyllucidone 1195233-59-0 B0005-161896 Sulfuretin 120-05-8 120926-46-7 Isoliquiritin apioside 120926-46-7 123316-64-3 2'-O-Methylhelichrysetin 123316-64-3 129724-43-2 2' 4'-Dihydroxy-3' 6'-dimethoxychalcone 129724-43-2... read more
45-16 Ramsey Road, Shirley, NY 11967, USA, Shirley, NY
Inhibition of BRPF1 There are two types of BRPF1 inhibitors reported on the basis of structures: 1 3-dimethylbenzimidazolone and N-methylquinoline-2-ketone. GSK6853 is a BRPF1 bromodomain inhibitor with high selectivity developed by GSK and other companies. The physicochemical properties of GSK6853 and good cellular activity will contribute to its cellular and in vivo studies as a chemical probe molecule for the biological functions of BRPF1 bromodomain. The N-methylquinoline-2-ketone compound NI-57 is a BRPF bromodomain inhibitor with Kd values of 31 110 and 410 nmol/L for BRPF1 BRPF2 and BRPF3 respectively. Experiments indicated that NI-57 showed an activity of submicromolar concentration on... read more
Inhibition of BRPF1 There are two types of BRPF1 inhibitors reported on the basis of structures: 1 3-dimethylbenzimidazolone and N-methylquinoline-2-ketone. GSK6853 is a BRPF1 bromodomain inhibitor with high selectivity developed by GSK and other companies. The physicochemical properties of GSK6853 and good cellular activity will contribute to its cellular and in vivo studies as a chemical probe molecule for the biological functions of BRPF1 bromodomain. The N-methylquinoline-2-ketone compound NI-57 is a BRPF bromodomain inhibitor with Kd values of 31 110 and 410 nmol/L for BRPF1 BRPF2 and BRPF3 respectively. Experiments indicated that NI-57 showed an activity of submicromolar concentration on... read more
45-16 Ramsey Road, Shirley, NY 11967, USA, Shirley, NY
An overview of Aryl hydrocarbon receptors Aryl hydrocarbon receptor belonging to the superfamily of basic helix loop helix/Per-Arnt-Sim proteins was identified as a cytosolic receptor for polycyclic aromatic hydrocarbon. Structurally the aryl hydrocarbon receptor consists of basic helix loop helix domain and Per-Arnt-Sim domain which are responsible for DNA binding and ligand binding. The sequence of aryl hydrocarbon receptor is composed of 848 amino acids and a molecular of 90 kDa. The aryl hydrocarbon receptor is expressed in vertebrate cells and plays key regulatory roles in normal physiology like immune inflammatory responses and atherogenesis. Besides aryl hydrocarbon receptor mediates function... read more
An overview of Aryl hydrocarbon receptors Aryl hydrocarbon receptor belonging to the superfamily of basic helix loop helix/Per-Arnt-Sim proteins was identified as a cytosolic receptor for polycyclic aromatic hydrocarbon. Structurally the aryl hydrocarbon receptor consists of basic helix loop helix domain and Per-Arnt-Sim domain which are responsible for DNA binding and ligand binding. The sequence of aryl hydrocarbon receptor is composed of 848 amino acids and a molecular of 90 kDa. The aryl hydrocarbon receptor is expressed in vertebrate cells and plays key regulatory roles in normal physiology like immune inflammatory responses and atherogenesis. Besides aryl hydrocarbon receptor mediates function... read more
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IRP Trucks, IFTA, FMSCA, ICC, UCR Illinois IRP Age has set up a shop in Lacartes Marketplace13 Apr 2024
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