NY
Manufacturers & Industrial
149 RESULTS WITHIN 50km FROM Philadelphia, United States
45-16 Ramsey Road, Shirley, NY 11967, USA, Shirley, NY
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Vascular endothelial growth factor (VEGF) a specific mitogen isolated from endothelial cells by researchers in the late 20th century has been shown to have the ability to induce physiological and pathological angiogenesis. The VEGF family is a multifunctional cytokine that mainly includes six members VEGF-A VEGF-B VEGF-C VEGF-D VEGF-E and placental growth factor (PLGF). In many tumors the level of expression is related to the degree of malignancy of the tumor. Mammalian angiogenesis begins with the formation of an embryonic vascular network. Under the induction of hypoxia or inflammatory disease pro-angiogenic factors such as VEGF bFGF and PDGF are produced... read more
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Vascular endothelial growth factor (VEGF) a specific mitogen isolated from endothelial cells by researchers in the late 20th century has been shown to have the ability to induce physiological and pathological angiogenesis. The VEGF family is a multifunctional cytokine that mainly includes six members VEGF-A VEGF-B VEGF-C VEGF-D VEGF-E and placental growth factor (PLGF). In many tumors the level of expression is related to the degree of malignancy of the tumor. Mammalian angiogenesis begins with the formation of an embryonic vascular network. Under the induction of hypoxia or inflammatory disease pro-angiogenic factors such as VEGF bFGF and PDGF are produced... read more
57 Broad St. 1A, Albany
Tel: 518-223-9346
Perfect Pave provides residential & commercial asphalt paving services in Albany New York. We also serve Latham Watervliet Cohoes and the surrounding areas of the Capital Region. We are your upstate paving contractors for blacktop driveways parking lots streets & more. Give us a call any day of the week to install repair or seal asphalt for homes or businesses.... read more
Tel: 518-223-9346
Perfect Pave provides residential & commercial asphalt paving services in Albany New York. We also serve Latham Watervliet Cohoes and the surrounding areas of the Capital Region. We are your upstate paving contractors for blacktop driveways parking lots streets & more. Give us a call any day of the week to install repair or seal asphalt for homes or businesses.... read more
W 53rd St & 7th Ave, New York City
Tel: (877) 207-9528
We are the professional water damage restoration service in new york city. We provide variety of damage restoration services like " water damage restoration nyc" mold removal nyc flood cleanup nyc etc. Visit our website for more details or call us and our trained and experienced professionals are available 24/7.... read more
Tel: (877) 207-9528
We are the professional water damage restoration service in new york city. We provide variety of damage restoration services like " water damage restoration nyc" mold removal nyc flood cleanup nyc etc. Visit our website for more details or call us and our trained and experienced professionals are available 24/7.... read more
45-16 Ramsey Road, Shirley, NY 11967, USA, Shirley, NY
BOC Sciences can provide a number of nucleotide related services including but not limited to: Gene Synthesis and Cloning Service Gene Mutagenesis Service Oligonucleotide Synthesis Service DNA Methylation Analysis Services Plasmid DNA Production Service Gene Expression Service We have lots of compounds in stock and our existing libraries of building blocks alongside with our specialized expertise allow short cut access to any desired novel nucleotide structure. In short we are convinced that our custom nucleotides synthesis service will meet or exceed your expectations. For additional information and for peptide synthesis pricing please contact us!... read more
BOC Sciences can provide a number of nucleotide related services including but not limited to: Gene Synthesis and Cloning Service Gene Mutagenesis Service Oligonucleotide Synthesis Service DNA Methylation Analysis Services Plasmid DNA Production Service Gene Expression Service We have lots of compounds in stock and our existing libraries of building blocks alongside with our specialized expertise allow short cut access to any desired novel nucleotide structure. In short we are convinced that our custom nucleotides synthesis service will meet or exceed your expectations. For additional information and for peptide synthesis pricing please contact us!... read more
45-16 Ramsey Road, Shirley, NY 11967, USA, Shirley, NY
Application Nucleoside analogues are used as antiviral or anticancer agents in medicine. Several analogues of the sugar backbone exist in molecular biology which are more stable alternative nucleoside/nucleotide analogues including LNA morpholino PNA. Dideoxynucleotides are used in sequencing. These nucleotides possess the non-canonical sugar dideoxyribose which lacks 3’ hydroxyl group (which accepts the phosphate) therefore it cannot bond with the next base and terminates the chain. Our Services BOC Sciences is a leading biotechnology company which has years of professional and abundant experience in providing nucleoside synthesis service for customers all over the world. BOC Sciences’s sophisticated equipments advanced technologies... read more
Application Nucleoside analogues are used as antiviral or anticancer agents in medicine. Several analogues of the sugar backbone exist in molecular biology which are more stable alternative nucleoside/nucleotide analogues including LNA morpholino PNA. Dideoxynucleotides are used in sequencing. These nucleotides possess the non-canonical sugar dideoxyribose which lacks 3’ hydroxyl group (which accepts the phosphate) therefore it cannot bond with the next base and terminates the chain. Our Services BOC Sciences is a leading biotechnology company which has years of professional and abundant experience in providing nucleoside synthesis service for customers all over the world. BOC Sciences’s sophisticated equipments advanced technologies... read more
45-16 Ramsey Road, Shirley, NY 11967, USA, Shirley, NY
Tel:
Accumulation of β-amyloid plaque is the hallmark of AD in the patients’ brain. γ-secretase is thought to contribute to the development of Alzheimer’s disease by generating β-amyloid peptides (Aβ peptides) particularly those that are prone to aggregation such as Aβ42. Aβ peptides are generated through the processing of amyloid precursor protein (APP) by β-secretase and γ-secretase in a stepwise fashion. After the β-secretase enzyme (BACE1 aspartyl protease) cleaves the APP extracellular domain γ-secretase cleaves the remaining part to release the Aβ peptide and the AICD (App intracellular domain).The AICD will regulate the calcium signal in the nucleus. And The Aβ... read more
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Accumulation of β-amyloid plaque is the hallmark of AD in the patients’ brain. γ-secretase is thought to contribute to the development of Alzheimer’s disease by generating β-amyloid peptides (Aβ peptides) particularly those that are prone to aggregation such as Aβ42. Aβ peptides are generated through the processing of amyloid precursor protein (APP) by β-secretase and γ-secretase in a stepwise fashion. After the β-secretase enzyme (BACE1 aspartyl protease) cleaves the APP extracellular domain γ-secretase cleaves the remaining part to release the Aβ peptide and the AICD (App intracellular domain).The AICD will regulate the calcium signal in the nucleus. And The Aβ... read more
45-16 Ramsey Road, Shirley, NY 11967, USA, Shirley, NY
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The p53 gene is an important tumor suppressor gene and its encoded p53 protein plays a key role in cell cycle regulation DNA repair and induction of apoptosis. Mutation of the p53 gene is one of the important factors in tumorigenesis. The p53 gene is mutated in more than 50% of cancer types which causes the p53 signaling pathway to lose the function of cell growth "brakes". The wild-type p53 protein is located at the intersection of the cell signaling and death signaling networks and plays a decisive role in cell growth differentiation senescence stress and apoptosis. At the same... read more
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The p53 gene is an important tumor suppressor gene and its encoded p53 protein plays a key role in cell cycle regulation DNA repair and induction of apoptosis. Mutation of the p53 gene is one of the important factors in tumorigenesis. The p53 gene is mutated in more than 50% of cancer types which causes the p53 signaling pathway to lose the function of cell growth "brakes". The wild-type p53 protein is located at the intersection of the cell signaling and death signaling networks and plays a decisive role in cell growth differentiation senescence stress and apoptosis. At the same... read more
45-16 Ramsey Road, Shirley, NY 11967, USA, Shirley, NY
XL147 - CAS 956958-53-5 Catalog number: B0084-258924 Category: Inhibitor Not Intended for Therapeutic Use. For research use only. Molecular Formula C21H16N6O2S2 Molecular Weight 448.52 COA Inquire Targets PI3K Description Pilaralisib is a Class 1 phosphatidylinositol 3 kinase (PI3K) family inhibitor. It is an orally bioavailable small molecule targeting the class I PI3K family of lipid kinases. It is a pyrimidine derivatives compound discovered by Exelixis Inc. It has potential antineoplastic activity. It binds to class 1 PI3Ks in an ATP-competitive manner by inhibiting the production of the secondary messenger phosphatidylinositol-3 4 5-trisphosphate (PIP3) and inhibiting the activation of the PI3K... read more
XL147 - CAS 956958-53-5 Catalog number: B0084-258924 Category: Inhibitor Not Intended for Therapeutic Use. For research use only. Molecular Formula C21H16N6O2S2 Molecular Weight 448.52 COA Inquire Targets PI3K Description Pilaralisib is a Class 1 phosphatidylinositol 3 kinase (PI3K) family inhibitor. It is an orally bioavailable small molecule targeting the class I PI3K family of lipid kinases. It is a pyrimidine derivatives compound discovered by Exelixis Inc. It has potential antineoplastic activity. It binds to class 1 PI3Ks in an ATP-competitive manner by inhibiting the production of the secondary messenger phosphatidylinositol-3 4 5-trisphosphate (PIP3) and inhibiting the activation of the PI3K... read more
45-16 Ramsey Road, Shirley, NY 11967, USA, Shirley, NY
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Duvelisib also known as IPI-145 and INK-1197 is an orally bioavailable highly selective and potent small molecule inhibitor of the delta and gamma isoforms of phosphoinositide-3 kinase (PI3K) with potential immunomodulating and antineoplastic activities. Upon administration PI3K delta/gamma inhibitor IPI 145 prevents the activation of the PI3K delta/gamma-mediated signaling pathways which may lead to a reduction in cellular proliferation in PI3K delta/gamma-expressing tumor cells. Unlike other isoforms of PI3K the delta and gamma isoforms are overexpressed primarily in hematologic malignancies and inflammatory and autoimmune diseases. By selectively targeting these PI3K isoforms PI3K signaling in normal non-neoplastic cells is minimally or... read more
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Duvelisib also known as IPI-145 and INK-1197 is an orally bioavailable highly selective and potent small molecule inhibitor of the delta and gamma isoforms of phosphoinositide-3 kinase (PI3K) with potential immunomodulating and antineoplastic activities. Upon administration PI3K delta/gamma inhibitor IPI 145 prevents the activation of the PI3K delta/gamma-mediated signaling pathways which may lead to a reduction in cellular proliferation in PI3K delta/gamma-expressing tumor cells. Unlike other isoforms of PI3K the delta and gamma isoforms are overexpressed primarily in hematologic malignancies and inflammatory and autoimmune diseases. By selectively targeting these PI3K isoforms PI3K signaling in normal non-neoplastic cells is minimally or... read more
45-16 Ramsey Road, Shirley, NY 11967, USA, Shirley, NY
Tel:
RO4929097 a small-molecule inhibitor of γ secretase (IC50= 4 nM EC50= 5 nM) inhibits cellular processing of Aβ40 (EC50= 14 nM) and Notch(EC50= 5 nM). In vitro: Decreases the amount of Aβ peptides secreted into the culture medium in HEK293 cells (EC50= 14 nM); Strongly inhibits Notch processing (EC50= 5 nM) in the Notch cell-based reporter assay In vivo: Oral injection of 3 to 60 mg/kg RO4929097 once daily or twice daily to nude mice bearing A549 NSCLC xenografts for either 7 14 or 21 days of a 21-day schedule results in significant tumor growth inhibition compared with vehicle-treated animals.... read more
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RO4929097 a small-molecule inhibitor of γ secretase (IC50= 4 nM EC50= 5 nM) inhibits cellular processing of Aβ40 (EC50= 14 nM) and Notch(EC50= 5 nM). In vitro: Decreases the amount of Aβ peptides secreted into the culture medium in HEK293 cells (EC50= 14 nM); Strongly inhibits Notch processing (EC50= 5 nM) in the Notch cell-based reporter assay In vivo: Oral injection of 3 to 60 mg/kg RO4929097 once daily or twice daily to nude mice bearing A549 NSCLC xenografts for either 7 14 or 21 days of a 21-day schedule results in significant tumor growth inhibition compared with vehicle-treated animals.... read more
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IRP Trucks, IFTA, FMSCA, ICC, UCR Illinois IRP Age has set up a shop in Lacartes Marketplace13 Apr 2024
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