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149 RESULTS WITHIN 50km FROM Philadelphia, United States
45-16 Ramsey Road, Shirley, NY 11967, USA, Shirley, NY
An Overview of 15-PGDH 15-hydroxy prostaglandin dehydrogenase (15-PGDH) is an important rate limiting enzyme for PG degradation and an inhibitor of COX-2. The 15-PGDH gene is located on the 4q34~q35 of chromosome 4 which is about 31KB and there are 7 exons and the molecular weight is 29kD which can catalyze the conversion of 15-PGDH into a 15- ketone metabolite with greatly reduced activity. 15-PGDH is divided into two subtypes: nicotinamide adenine dinucleotide NAD+ dependent 15-PGDH (type I) and NADP+ dependent 15-PGDH (type II). 15-PGDH is widely found in normal tissues such as the lungs kidneys gastrointestinal tract thyroid prostate... read more
An Overview of 15-PGDH 15-hydroxy prostaglandin dehydrogenase (15-PGDH) is an important rate limiting enzyme for PG degradation and an inhibitor of COX-2. The 15-PGDH gene is located on the 4q34~q35 of chromosome 4 which is about 31KB and there are 7 exons and the molecular weight is 29kD which can catalyze the conversion of 15-PGDH into a 15- ketone metabolite with greatly reduced activity. 15-PGDH is divided into two subtypes: nicotinamide adenine dinucleotide NAD+ dependent 15-PGDH (type I) and NADP+ dependent 15-PGDH (type II). 15-PGDH is widely found in normal tissues such as the lungs kidneys gastrointestinal tract thyroid prostate... read more
45-16 Ramsey Road, Shirley, NY 11967, USA, Shirley, NY
An Overview of 5-lipoxygenase 5-lipoxygenase (5-LOX) is an important kind of dioxygenase and a kind of LOX isozyme in organism. It is widely found in the tissues and blood of most mammals. The molecular weight of 5-lipoxygenase is 75 ~ 80kD including 673 amino acids. 5-LOX mainly consists of two domains of which the C2 domain which is composed of 120 amino acids at the N-terminal can bind to Ca2+ as well as a large catalytic domain. When stimulated by inflammatory factors activated cytosolic phosphatase A2 (CPLA2) stimulated membrane phospholipid release of arachidonic acid (AA). At this point the precursor... read more
An Overview of 5-lipoxygenase 5-lipoxygenase (5-LOX) is an important kind of dioxygenase and a kind of LOX isozyme in organism. It is widely found in the tissues and blood of most mammals. The molecular weight of 5-lipoxygenase is 75 ~ 80kD including 673 amino acids. 5-LOX mainly consists of two domains of which the C2 domain which is composed of 120 amino acids at the N-terminal can bind to Ca2+ as well as a large catalytic domain. When stimulated by inflammatory factors activated cytosolic phosphatase A2 (CPLA2) stimulated membrane phospholipid release of arachidonic acid (AA). At this point the precursor... read more
45-16 Ramsey Road, Shirley, NY 11967, USA, Shirley, NY
Tel: 16316197922
Chiral resolution as an important tool in the production of optically active drugs is a process for the separation of racemic compounds into their enantiomers in the aspect of stereochemistry. Particularly when the methods of stereospecific synthesis designed for one of the enantiomers at present lead generally to enhanced enantioselectivity not only the development of analytical methods for the chiral separation to control optical purity of a large number of pharmaceuticals/therapeutics administered today but also the development of methods for quantitative large-scale separation from their racemic or enantiomeric mixture are required and are the challenges for chemists and open wider... read more
Tel: 16316197922
Chiral resolution as an important tool in the production of optically active drugs is a process for the separation of racemic compounds into their enantiomers in the aspect of stereochemistry. Particularly when the methods of stereospecific synthesis designed for one of the enantiomers at present lead generally to enhanced enantioselectivity not only the development of analytical methods for the chiral separation to control optical purity of a large number of pharmaceuticals/therapeutics administered today but also the development of methods for quantitative large-scale separation from their racemic or enantiomeric mixture are required and are the challenges for chemists and open wider... read more
45-16 Ramsey Road, Shirley, NY 11967, USA, Shirley, NY
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A logical extension about the application of chiral ligands in stereoselective catalysis has been developed. In general ligands design in asymmetric catalysis is guided by several simple concepts and principles. For instance the design of chiral ligands is frequently based on C2-symmetry in order to reduce the number of diastereomeric intermediates and transition states which play a role in the catalytic cycle. This approach has been vindicated by the successful development of several large families of (“privileged”) chiral ligands which nowadays belong to the basic “tool kit” of asymmetric catalysis such as chiral diphosphines salen derivatives and bisoxazolines. These privileged... read more
Tel:
A logical extension about the application of chiral ligands in stereoselective catalysis has been developed. In general ligands design in asymmetric catalysis is guided by several simple concepts and principles. For instance the design of chiral ligands is frequently based on C2-symmetry in order to reduce the number of diastereomeric intermediates and transition states which play a role in the catalytic cycle. This approach has been vindicated by the successful development of several large families of (“privileged”) chiral ligands which nowadays belong to the basic “tool kit” of asymmetric catalysis such as chiral diphosphines salen derivatives and bisoxazolines. These privileged... read more
45-16 Ramsey Road, Shirley, NY 11967, USA, Shirley, NY
Chemical libraries contain a collection of diversity of real or virtual chemical compounds which offers customers a powerful guarantee for custom synthesis. These custom libraries utilize an advanced chemistry-focused proprietary technology platform which meets the most challenging quality standards of the world's leading pharmaceutical companies.... read more
Chemical libraries contain a collection of diversity of real or virtual chemical compounds which offers customers a powerful guarantee for custom synthesis. These custom libraries utilize an advanced chemistry-focused proprietary technology platform which meets the most challenging quality standards of the world's leading pharmaceutical companies.... read more
45-16 Ramsey Road, Shirley, NY 11967, USA, Shirley, NY
Tel:
In general screening libraries contain amounts of compounds for the demands of academia and industry which is inconvenient for researchers to study in the specific areas. Activity-based libraries are designed for researchers with the classification of compounds according to their potential application in different fields of drug discovery which use combination of validated descriptors and compound properties.... read more
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In general screening libraries contain amounts of compounds for the demands of academia and industry which is inconvenient for researchers to study in the specific areas. Activity-based libraries are designed for researchers with the classification of compounds according to their potential application in different fields of drug discovery which use combination of validated descriptors and compound properties.... read more
45-16 Ramsey Road, Shirley, NY 11967, USA, Shirley, NY
As an efficient method to accelerate the process of drug discovery fragment screening has been widely recognized in academic and commercial fields. The FBDD method usually first determines the affinity of a water-soluble small molecule compound (relative molecular mass... read more
As an efficient method to accelerate the process of drug discovery fragment screening has been widely recognized in academic and commercial fields. The FBDD method usually first determines the affinity of a water-soluble small molecule compound (relative molecular mass... read more
45-16 Ramsey Road, Shirley, NY 11967, USA, Shirley, NY
Lead optimization is a diversified operation in drug discovery in which the chemical structures of compounds or biologics are modified to improve target’s specificity selectivity pharmacodynamics pharmacokinetic and toxicological properties to generate preclinical drug candidates. In order to understand the need for lead optimization it is important to determine the basic characteristics of leads and in order to make a compound a drug sample at least five basic attributes need to be considered including potency bioavailability duration safety and pharmaceutical acceptability.... read more
Lead optimization is a diversified operation in drug discovery in which the chemical structures of compounds or biologics are modified to improve target’s specificity selectivity pharmacodynamics pharmacokinetic and toxicological properties to generate preclinical drug candidates. In order to understand the need for lead optimization it is important to determine the basic characteristics of leads and in order to make a compound a drug sample at least five basic attributes need to be considered including potency bioavailability duration safety and pharmaceutical acceptability.... read more
45-16 Ramsey Road, Shirley, NY 11967, USA, Shirley, NY
Leucyl-tRNA synthetase cytoplasmic is an enzyme that in humans is encoded by the LARS gene Catalog Product Name CAS Number 1234563-16-6 Epetraborole HCl 1234563-16-6... read more
Leucyl-tRNA synthetase cytoplasmic is an enzyme that in humans is encoded by the LARS gene Catalog Product Name CAS Number 1234563-16-6 Epetraborole HCl 1234563-16-6... read more
45-16 Ramsey Road, Shirley, NY 11967, USA, Shirley, NY
Tel: 6316197922
Researchers from industry and academia have synthesized structurally diverse LpxC inhibitors exhibiting different LpxC inhibitory and antibacterial activities. Current search for novel LpxC inhibitors is focused on small molecules sharing common structural features like a Zn2+-chelating group as well as a highly lipophilic side-chain. However despite the promising preclinical data of many of the reported compounds no other LpxC inhibitor besides the recently withdrawn clinical candidate ACHN-975 has entered clinical trials. The lack of clinical candidates might be related with undesired effects caused by the common structural elements of the LpxC inhibitors. Among the disclosed compounds the N-aroyl-L-threonine- and methylsulfone-based... read more
Tel: 6316197922
Researchers from industry and academia have synthesized structurally diverse LpxC inhibitors exhibiting different LpxC inhibitory and antibacterial activities. Current search for novel LpxC inhibitors is focused on small molecules sharing common structural features like a Zn2+-chelating group as well as a highly lipophilic side-chain. However despite the promising preclinical data of many of the reported compounds no other LpxC inhibitor besides the recently withdrawn clinical candidate ACHN-975 has entered clinical trials. The lack of clinical candidates might be related with undesired effects caused by the common structural elements of the LpxC inhibitors. Among the disclosed compounds the N-aroyl-L-threonine- and methylsulfone-based... read more
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IRP Trucks, IFTA, FMSCA, ICC, UCR Illinois IRP Age has set up a shop in Lacartes Marketplace13 Apr 2024
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