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45-16 Ramsey Road, Shirley, NY 11967, USA, Shirley, NY
Major types of Prostanoid Receptor E-type prostanoid (EP) receptors are an important class of prostanoid receptor termed EP1 EP2 EP3 and EP4. EP1 was the first reported EP receptor and was found in kidney and lung tissue at a low level. The human EP1 receptor is composed of 402 amino acids sharing a sequence homology of 86% with the rat EP1 receptor. EP2 and EP4 have the similarities in pharmacology and functional coupling mediating celluar signaling via adenylate cyclase activity. The EP3 receptor is reported to have various isoforms that differ in the amino acid sequence of the C-terminal region.... read more
Major types of Prostanoid Receptor E-type prostanoid (EP) receptors are an important class of prostanoid receptor termed EP1 EP2 EP3 and EP4. EP1 was the first reported EP receptor and was found in kidney and lung tissue at a low level. The human EP1 receptor is composed of 402 amino acids sharing a sequence homology of 86% with the rat EP1 receptor. EP2 and EP4 have the similarities in pharmacology and functional coupling mediating celluar signaling via adenylate cyclase activity. The EP3 receptor is reported to have various isoforms that differ in the amino acid sequence of the C-terminal region.... read more
45-16 Ramsey Road, Shirley, NY 11967, USA, Shirley, NY
Major types of Tau Normal Tau protein can be divided into two kinds one is in the central nervous system (molecular weight 4500~6000) known as low molecular weight Tau (LMW-Tau). The other is found in the peripheral nervous system (about 9000 molecular weight) and is called high molecular weight Tau(HMW-Tau). Tau proteins are encoded by genes located on the long arm of chromosome 17. Because of the differences in mRNA of transcription products during post-transcriptional shearing and modification 6 isomers can be formed which are named Tau1~Tau6 respectively. They differ in the carboxyl terminal of 3R(3R-Tau) or 4R(4R-Tau). The six... read more
Major types of Tau Normal Tau protein can be divided into two kinds one is in the central nervous system (molecular weight 4500~6000) known as low molecular weight Tau (LMW-Tau). The other is found in the peripheral nervous system (about 9000 molecular weight) and is called high molecular weight Tau(HMW-Tau). Tau proteins are encoded by genes located on the long arm of chromosome 17. Because of the differences in mRNA of transcription products during post-transcriptional shearing and modification 6 isomers can be formed which are named Tau1~Tau6 respectively. They differ in the carboxyl terminal of 3R(3R-Tau) or 4R(4R-Tau). The six... read more
45-16 Ramsey Road, Shirley, NY 11967, USA, Shirley, NY
Antagonist of CD88 PMX 205 trifluoroacetate is an effective complement C5a receptor (C5aR; CD88) antagonists. W-54011 is an oral effective specific CD88 (C5a receptor) antagonist inhibiting the binding of 125i-labeled C5a to human neutrophilic granulocytes Ki = 2.2 nm. CD88 and diseases CD88 also known as C5aR is expressed in the parenchyma of human and rodent especially liver parenchyma cells lung smooth muscle cells lung capillary endothelial cells bronchial epithelial cells and alveolar epithelial cells. It is involved in a series of inflammatory processes and plays an important role in the pathophysiological processes such as acute lung injury sepsis rheumatoid... read more
Antagonist of CD88 PMX 205 trifluoroacetate is an effective complement C5a receptor (C5aR; CD88) antagonists. W-54011 is an oral effective specific CD88 (C5a receptor) antagonist inhibiting the binding of 125i-labeled C5a to human neutrophilic granulocytes Ki = 2.2 nm. CD88 and diseases CD88 also known as C5aR is expressed in the parenchyma of human and rodent especially liver parenchyma cells lung smooth muscle cells lung capillary endothelial cells bronchial epithelial cells and alveolar epithelial cells. It is involved in a series of inflammatory processes and plays an important role in the pathophysiological processes such as acute lung injury sepsis rheumatoid... read more
45-16 Ramsey Road, Shirley, NY 11967, USA, Shirley, NY
Tel: 6316197922
An overview of PKA PKA is a tetramer containing regulatory subunits and catalytic subunits with four regulatory subtypes (RIα RIβ RIIα RIIβ) and three catalytic subtypes (Cα Cβ Cγ). PKA belongs to the serine/threonine protein kinase. In the AC-cAMP-PKACREB pathway adenylate cyclase (AC) catalyzes the production of cyclic adenosine monophosphate (cAMP) by intracellular ATP. As an intracellular signaling substance cAMP is mainly activated by PKA to realize signal transduction. Its functions involve many aspects including the plasticity of synapse exocytosis and gene transcription. PKA is expressed throughout the brain especially in the cerebral cortex thalamus and amygdala. Moreover it is... read more
Tel: 6316197922
An overview of PKA PKA is a tetramer containing regulatory subunits and catalytic subunits with four regulatory subtypes (RIα RIβ RIIα RIIβ) and three catalytic subtypes (Cα Cβ Cγ). PKA belongs to the serine/threonine protein kinase. In the AC-cAMP-PKACREB pathway adenylate cyclase (AC) catalyzes the production of cyclic adenosine monophosphate (cAMP) by intracellular ATP. As an intracellular signaling substance cAMP is mainly activated by PKA to realize signal transduction. Its functions involve many aspects including the plasticity of synapse exocytosis and gene transcription. PKA is expressed throughout the brain especially in the cerebral cortex thalamus and amygdala. Moreover it is... read more
45-16 Ramsey Road, Shirley, NY 11967, USA, Shirley, NY
Tel: 6316197922
iGluR Catalog Product Name CAS Number CNQX 115066-14-3 24-Hydroxycholesterol 30271-38-6 Kainic acid 487-79-6 UBP 301 569371-10-4 UBP 296 745055-86-1 UBP 302 745055-91-8 UBP 310 902464-46-4... read more
Tel: 6316197922
iGluR Catalog Product Name CAS Number CNQX 115066-14-3 24-Hydroxycholesterol 30271-38-6 Kainic acid 487-79-6 UBP 301 569371-10-4 UBP 296 745055-86-1 UBP 302 745055-91-8 UBP 310 902464-46-4... read more
45-16 Ramsey Road, Shirley, NY 11967, USA, Shirley, NY
Tel: 16316197922
An overview of autophagy Just as cells must manufacture necessary components for proper function so must they break down damaged or unnecessary organelles and other cellular constituents. In order to maintain this balance the cells employ two primary degradative pathways. The first is the proteasome which is responsible for the breakdown of most short-lived proteins. The second is autophagy a process induced by nutrient limitation and cellular stress which governs the degradation of the majority of long-lived proteins protein aggregates and whole organelles. It enables cells to survive stress from the external environment such as nutrient deprivation as well as... read more
Tel: 16316197922
An overview of autophagy Just as cells must manufacture necessary components for proper function so must they break down damaged or unnecessary organelles and other cellular constituents. In order to maintain this balance the cells employ two primary degradative pathways. The first is the proteasome which is responsible for the breakdown of most short-lived proteins. The second is autophagy a process induced by nutrient limitation and cellular stress which governs the degradation of the majority of long-lived proteins protein aggregates and whole organelles. It enables cells to survive stress from the external environment such as nutrient deprivation as well as... read more
45-16 Ramsey Road, Shirley, NY 11967, USA, Shirley, NY
Tel: 6316197922
An Overview of WD repeat-containing protein 5 (WDR5) WD repeat-containing protein 5 (WDR5) is a member of the WD-40 protein family and is also an important component of the chromosomal H3 modified protein complex Trithorax group (Trx G). WDR5 is composed of 333 amino acids and its peptide chain contains 7 WD repeats to form a β-sheet which is the main functional domain of WDR5. As a member of the WD40 family it is widely involved in the regulation of gene expression in organisms and plays a huge role in the activation of mixed lineage leukemia tumor formation assembly of... read more
Tel: 6316197922
An Overview of WD repeat-containing protein 5 (WDR5) WD repeat-containing protein 5 (WDR5) is a member of the WD-40 protein family and is also an important component of the chromosomal H3 modified protein complex Trithorax group (Trx G). WDR5 is composed of 333 amino acids and its peptide chain contains 7 WD repeats to form a β-sheet which is the main functional domain of WDR5. As a member of the WD40 family it is widely involved in the regulation of gene expression in organisms and plays a huge role in the activation of mixed lineage leukemia tumor formation assembly of... read more
45-16 Ramsey Road, Shirley, NY 11967, USA, Shirley, NY
Tel: 6316197922
An Overview of Vesicular monoamine transporter 2 (VMAT2) Vesicular monoamine transporter 2 (VMAT2) is a protein that transports neurotransmitters and belongs to a subtype of vesicular monoamine transporters. VMAT2 is a glycoprotein that binds to the vesicle membrane and is an essential protein that constitutes the human body. It transports monoamines especially dopamine norepinephrine serotonin and histamine from the cellular cytoplasm to synaptic vesicles. VMAT2 has approximately 518 amino acids. The Vesicular monoamine transporter’s relative molecular mass and the number of amino acids in different species are slightly different. Prediction of its molecular structure from the VMAT2 protein sequence revealed... read more
Tel: 6316197922
An Overview of Vesicular monoamine transporter 2 (VMAT2) Vesicular monoamine transporter 2 (VMAT2) is a protein that transports neurotransmitters and belongs to a subtype of vesicular monoamine transporters. VMAT2 is a glycoprotein that binds to the vesicle membrane and is an essential protein that constitutes the human body. It transports monoamines especially dopamine norepinephrine serotonin and histamine from the cellular cytoplasm to synaptic vesicles. VMAT2 has approximately 518 amino acids. The Vesicular monoamine transporter’s relative molecular mass and the number of amino acids in different species are slightly different. Prediction of its molecular structure from the VMAT2 protein sequence revealed... read more
45-16 Ramsey Road, Shirley, NY 11967, USA, Shirley, NY
Tel: 16316197922
An Overview of TSPO Translocator protein (TSPO) used to be called the peripheral benzodiazepine receptor (PBR). In 1977 Braestrup et al. accidentally discovered and confirmed the TSPO when they used rat peripheral tissue as a negative control of the central nervous system (CNS) in radioligand binding experiments. In 2005 Papadopoulos et al. proposed to name the first subunit in PBR the isoquinoline binding site inhibitor as TSPO. TSPO is a ubiquitous and highly conserved protein encoded by nuclear DNA. TSPO contains 169 amino acids and 5 transmembrane helices and is a hydrophobic 1.8×103 protein composed of 5 isoquinoline binding proteins.... read more
Tel: 16316197922
An Overview of TSPO Translocator protein (TSPO) used to be called the peripheral benzodiazepine receptor (PBR). In 1977 Braestrup et al. accidentally discovered and confirmed the TSPO when they used rat peripheral tissue as a negative control of the central nervous system (CNS) in radioligand binding experiments. In 2005 Papadopoulos et al. proposed to name the first subunit in PBR the isoquinoline binding site inhibitor as TSPO. TSPO is a ubiquitous and highly conserved protein encoded by nuclear DNA. TSPO contains 169 amino acids and 5 transmembrane helices and is a hydrophobic 1.8×103 protein composed of 5 isoquinoline binding proteins.... read more
45-16 Ramsey Road, Shirley, NY 11967, USA, Shirley, NY
Tel: 16316197922
An Overview of Trace amine-associated receptor 1 (TAAR1) In 2001 two independent research groups Borowski et al. and Bunzow et al. firstly discovered trace amine related receptor 1 (TAAR1) which is a trace amine related receptor (TAAR) protein encoded by the TAAR1 gene of humans beings. The structure of TAAR1 is similar to the A-type rhodopsin GPCR subfamily which has seven transmembrane domains with short N and C terminal extensions. TAAR1 is an intracellular amine-activated Gs-coupled and Gq-coupled G-protein coupled receptor (GPCR). TAAR1 is expressed mainly in the intracellular environment of the presynaptic plasma membrane of several peripheral organs and... read more
Tel: 16316197922
An Overview of Trace amine-associated receptor 1 (TAAR1) In 2001 two independent research groups Borowski et al. and Bunzow et al. firstly discovered trace amine related receptor 1 (TAAR1) which is a trace amine related receptor (TAAR) protein encoded by the TAAR1 gene of humans beings. The structure of TAAR1 is similar to the A-type rhodopsin GPCR subfamily which has seven transmembrane domains with short N and C terminal extensions. TAAR1 is an intracellular amine-activated Gs-coupled and Gq-coupled G-protein coupled receptor (GPCR). TAAR1 is expressed mainly in the intracellular environment of the presynaptic plasma membrane of several peripheral organs and... read more
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IRP Trucks, IFTA, FMSCA, ICC, UCR Illinois IRP Age has set up a shop in Lacartes Marketplace13 Apr 2024
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